![]() ![]() Lymphadenopathy is considered localized if no more than two contiguous lymph node groups are involved. The presence or absence of tenderness does not reliably differentiate benign from malignant nodes. Pain and tenderness is usually the result of an inflammatory process or suppuration within the nodes but may also represent hemorrhage into the necrotic center of a malignant node. A group of nodes that feel connected and seem to move as a unit is said to be matted and can be either benign (e.g., tuberculosis, sarcoidosis, lymphogranuloma venereum, and human immunodeficiency virus ) or malignant (e.g., metastatic carcinoma and lymphoma). The term shotty refers to small nodes that feel like “buckshot” under the skin, as found in the cervical nodes of children with viral illnesses. Softer nodes are the result of infectious or inflammatory conditions and when suppuration is present, these nodes may tend to be fluctuant. ![]() Very firm, rubbery nodes suggest lymphoma. Stony-hard nodes are usually a sign of malignancy. A thorough examination must include the location of lymphadenopathy including an evaluation of all accessible lymph node-bearing areas, the size and consistency of palpated nodes, whether they are discrete or matted and whether tenderness is present and, if so, at what level of severity.Īs a general rule, a node larger than 1 cm should be considered abnormal. Important elements of the history should also include the presence or absence of pain, occupational and animal exposures, geographic residence, travel history, sexual and drug use behavior, trauma and presence or absence of systemic symptoms, and/or history of underlying disease. ![]()
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